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. Author manuscript; available in PMC: 2016 Mar 15.
Published in final edited form as: Clin Cancer Res. 2014 Dec 23;21(6):1466–1476. doi: 10.1158/1078-0432.CCR-14-2072

Figure 2. AKR1B8 deficiency interrupts growth and homeostasis of mouse colonic crypts.

Figure 2

(A) H&E histology (n=30 each); (B) PCNA expression (n=5 each); (C) BrdU labeling at 1, 24, and 48 hours (n=5 each); (D) Upper panel, ITF expression; and lower panel, Alcian blue and Periodic acid Schiff staining (n=5 each). Scale bar indicates 100 µm. (E) Western blot of acetyl-CoA carboxylase-α (ACCA) protein; (F) Incorporation of 14C-butyric acid into total lipids and various species: phospholipids (PL), triglycerides (TG), free fatty acids, and cholesterol (CH). n=5 each; *, P<0.05 and **, P<0.01 compared to wild type. Statistical significance was tested by One-way Anova test.