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Simulated response probability at different EPSP amplitudes and synaptic noise levels. A: accurate estimate (A = 9 mV; σ = 4 mV). B: an underestimate due to low noise level (σ = 3 mV) with A = 9 mV. C: an overestimate due to high EPSP amplitude (A = 10 mV) at a given noise level (σ = 4 mV).