Table 1.
Summary of electrophysiological intrinsic membrane properties of subclasses of interneurons in layer 3 of monkey DLPFC
| Cell Class | Time Constant, ms | Input Resistance, MΩ | Spike Duration, ms | Adaptation Ratio (last ISI/first ISI) | Spike Threshold, mV | AHP Amplitude, mV |
|---|---|---|---|---|---|---|
| FS (n = 34) | 9.21 ± 0.62a | 155 ± 16a | 0.45 ± 0.01a | 1.07 ± 0.02a | −50.5 ± 1.0a | 18.9 ± 1.1a |
| RS (n = 24) | 22.40 ± 1.48b | 318 ± 32b | 0.84 ± 0.05b | 2.03 ± 0.13b | −51.8 ± 1.9a | 12.0 ± 0.9b |
| BS (n = 6) | 22.51 ± 5.49b | 292 ± 26b | 1.09 ± 0.11c | 4.17 ± 0.87b | −55.6 ± 1.4a | 5.7 ± 1.5c |
| IS (n = 6) | 14.3 ± 1.6a,b | 288 ± 72b | 0.66 ± 0.11b | 3.23 ± 0.69b | −53.5 ± 1.6a | 12.9 ± 2.4b |
Except for spike threshold, all other electrophysiological properties showed significant differences between group means, as determined by single-factor ANOVA. In each column, groups labeled with a different letter are significantly different, as determined by Fisher least significant difference (LSD) comparisons (P < 0.05).
DLPFC, dorsolateral prefrontal cortex; FS, fast spiking; RS, regular spiking; BS, burst spiking; IS, irregular spiking; ISI, interspike interval; AHP, afterhyperpolarization.