Table 1.
Similar D1 agonism-induced enhancement of dorsal striatum-evoked, middle striatum-evoked, and local SNr-evoked striatonigral IPSCs
| Mice | Bath-applied D1R Agonist | Dorsal Striatum-evoked Striatonigral IPSC (C), %increase | Middle Striatum-evoked Striatonigral IPSC (D), % increase | Ventral Striatum-evoked Striatonigral IPSC (E), % increase | Local SNr-evoked Striatonigral IPSC (F), % increase |
|---|---|---|---|---|---|
| Pitx3WT (A) | SKF81297 (1 μM) | 49.9 ± 8.4* | 43.3 ± 5.3 | 46.5 ± 10.0 | 41.4 ± 7.2 |
| Pitx3Null (B) | SKF81297 (1 μM) | 94.1 ± 7.2†‡ | 95.3 ± 14.2‡ | 94.7 ± 6.8‡ | 75.4 ± 4.8‡ |
WT, wild type; D1R, D1 receptor; IPSC, inhibitory postsynaptic current; SNr, substantia nigra pars reticulata.
*
C vs. D vs. E vs. F: P > 0.5;
†
C vs. D vs. E vs. F: P > 0.1;
‡
A vs. B: P < 0.01: one-way ANOVA followed by post hoc least significant difference test.