Table 3.

Comparison of active and passive properties of type I DG granule cells under different experimental conditions

	Wild-type, n = 19	Tg2576, n = 18	Tg2576 + RSG, n = 26	P
First peak latency, ms	159.2 ± 21	270.8 ± 23.2	273.9 ± 25.2	0.002*
Itrh, pA	25.3 ± 2.7	30.6 ± 2.7	26.9 ± 2	0.3*
Vtrh, mV	−48.6 ± 1.1	−43.9 ± 2	−45.8 ± 1.2	0.03†
MRP, mV	−59.6 ± 1.4	−66.6 ± 1.6	−64.7 ± 1.6	0.01*
Rin, MΩ	443.3 ± 19.9	419.1 ± 16.4	440.6 ± 11.7	0.5*
τ, ms	26.1 ± 1.5	32.6 ± 2.3	28.5 ± 1.6	0.02‡
Cm, pF	62.3 ± 5.8	79.3 ± 5.6	66.9 ± 4.3	0.03†

Tg2576- and RSG-treated Tg2576 were compared with wild-type. Data are mean ± SE.

^*P values obtained with 1-way ANOVA and post hoc Dunnett test;

^†P values were obtained with post hoc Fisher test; and

^‡P values obtained with post hoc Dunnett test.

V_trh, voltage threshold; MRP, membrane resting potential; τ, time constant; C_m, membrane capacitance.