Table 4.

Comparison of firing, active, and passive properties of type I DG granule cells between wild-type and RSG-treated wild-type

DG GC Type I	Wild-type, n = 19	Wild-type + RSG, n = 16	P
MRP, mV	−59.6 ± 1.4	−61.9 ± 1.7	0.3
Vtrh, mV	−48.6 ± 1.1	−44.9 ± 1.1	0.03*
Itrh, mV	25.3 ± 2.7	30 ± 2	0.18
Cm, pF	62.3 ± 5.8	67.6 ± 3.6	0.46
Rin, MΩ	443.3 ± 19.9	444.5 ± 16.5	0.96
τ, ms	26.05 ± 1.5	29.9 ± 1.8	0.1
fAHP, mV	−11.8 ± 1.2	−12.4 ± 1.4	0.74
ADP, mV	3.9 ± 0.7	4.6 ± 0.6	0.47
sAHP, mV	−10.8 ± 1.05	−11.1 ± 1.1	0.85
Number of APs at Current Step of
20, pA	5 ± 0.9	3.3 ± 1.2	0.31
30, pA	7.3 ± 0.8	3.6 ± 0.6	0.002*
40, pA	9.05 ± 0.9	5.9 ± 0.7	0.01*
50, pA	10.7 ± 0.9	8.2 ± 0.7	0.04*
60, pA	12.3 ± 1.02	10.2 ± 0.7	0.09
Instantaneous Firing Frequency (Hz) at Current Step of
50, pA	24.6 ± 2.3	18.1 ± 1.3	0.02*
90, pA	39.4 ± 3.5	29.9 ± 1.6	0.02*
110, pA	45.3 ± 3.9	34.6 ± 1.8	0.02*
140, pA	54.4 ± 5.1	40.9 ± 2.2	0.02*

Data are mean ± SE.

^*P values obtained with Student's t-test.

GC, granule cell; fAHP, fast after-hyperpolarization; ADP, after-depolarization; sAHP, slow AHP.