Fig. 10.

Depolarized-induced suppression of excitation (DSE) is potentiated in POMC neurons from TP-treated animals and blocked by the CB1 receptor antagonist AM251. The representative membrane current traces illustrate the changes in spontaneous excitatory postsynaptic current (sEPSC) frequency and amplitude elicited by DSE during recordings in slices from vehicle- (A) and TP-treated animals (B) as well as in slices pretreated with AM251 (C). The rectangular wave under the arrow labeled DSE represents the truncated change in membrane current caused by the 3-s, 60-mV depolarizing voltage command.