Third ventricular administration of AM251 appreciably attenuates the hyperphagic effect of TP. Bars represent means and vertical lines 1 SE of energy intake monitored at 1, 2, 4, 16, and 24 h after treatment with TP (400 μg sc) and/or AM251 [10 μg into the 3rd ventricle (I3V)] or their respective vehicles. #Values from TP-treated animals that are significantly different (P < 0.05, multifactorial ANOVA/LSD; n = 4–6) from those from their vehicle-treated counterparts; *values from AM251-treated animals that are significantly different (P < 0.05, multifactorial ANOVA/LSD; n = 4–6) from vehicle-treated controls.