Fig. 2.
The effect on breathing over time of dialysis of Spantide (SPA) in the day at three different doses (133 μM, n = 7; 267 μM, n = 5; 500 μM, n = 6) was not significantly (P ≥ 0.115) different from the effect of time control studies (n = 7). A: minute ventilation (VI, liter/min); B: frequency (F, br/min); C: tidal volume (VT, liter/br). First data point represents last bin of Hour 1. Closed symbols and bar indicate period of SPA dialysis (Hour 2); open symbols indicate mCSF dialysis. F and P indicate values for interaction term from two-way repeated-measures (RM) ANOVA (see methods for further details on statistical analysis).