Fig. 4.

Dialysis of 3 mM RP in the day (n = 7) significantly increased the effluent concentrations of 5-HT (A), Substance P (SP) (C), and glycine (GLY) (D) (P ≤ 0.025). RP significantly decreased effluent concentrations of glutamine (GLN) (B) and thyrotropin-releasing hormone (TRH) (E) (P ≤ 0.034), but had no effect on GABA (F) (P = 0.183). x Axis indicates hour of dialysis. Closed bars indicate RP dialysis; open bars indicate mock cerebrospinal fluid (mCSF) dialysis. Bars on the left represent time control studies (n = 7); bars on the right represent RP studies. P values are from two-way RM ANOVA (A–D, F) or paired t-test (E).