Fig. 1.

Effect of Na⁺ or water loading on inner medullary collecting duct (IMCD) endothelin (ET)-1 mRNA content in rats (A) and mice (B). For Na⁺ loading, rats and mice were fed a normal NaCl (0.25%) or high-NaCl (8%) diet for 3 days. For water loading, rats and mice were fed 1% sucrose in normal drinking water for 3 days. n = 3 for each data point. *P < 0.05 vs. animals fed a normal NaCl and water diet.