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MitoQ prevents decreases in desmin protein expression. Western blot analysis of desmin indicated a significant decrease in desmin whole-length protein in 8- wk ACF rats, corresponding to the loss of desmin shown in Fig. 5. The appearance of a lower-molecular-weight breakdown product accompanied this decrease in full-length protein at 53 kDa. The decrease in the 53-kDa desmin band in ACF was rescued by treatment with MitoQ, leading to a decrease in the breakdown product band.
