Fig. 1.

nuclear transcription factor erythroid 2p45-related factor-2 knockout (Nrf2^−/−) and wild-type (WT) mice show similar cerebrovascular architecture. Anastomosis was assessed to determine potential variations in the cerebral vasculature of WT and Nrf2^−/− mice. A and B: representative images from C57BL/6 WT and Nrf2^−/− mice show line tracings connecting anastomosis points. C and D: no significant differences were found in the mean intersection distance from the midline or the total number of anastomoses, indicating that cerebral vascular physiology is similar. Data are expressed as mean ± SD.