Fig. 3.

OVX mice reduced time spent in the correct quadrant of the Barnes maze during the probe trial compared with intact female mice, particularly in IH-exposed mice (C). Male mice exposed to IH reduced time spent in the correct quadrant of the Barnes maze during the probe trial compared with RA-exposed mice (D), indicating impaired memory. Values are means ± SE for number of nose pokes into the escape hole in female (A) and male mice (B). Values are means ± SE for time spent in the correct quadrant of the Barnes maze during the probe trial in female mice (C) and male mice (D). Significant mean differences at P < 0.05 indicated by different letters above groups (e.g., a vs. b) as determined by Tukey's HSD post hoc.