Table 2.
Characterization of the first detectable antibody titers to Epstein-Barr virus (EBV) viral capsid antigen (VCA), early antigen (EA), and nuclear antigen (EBNA) in human immunodeficiency virus (HIV)–infected and HIV-uninfected children born to HIV-infected mothers.
| Group and antigen | Geometric mean titer ± SE |
Median (range) |
|---|---|---|
| HIV-1 infected | ||
| VCA | ||
| VCA-IgMa | 20 ± 5 | 16 (8–256) |
| VCA-IgGb | 403 ± 81 | 320 (10–20,480) |
| EAs (n = 37) | 157 ± 51e | 160 (10–20,480) |
| EA-D (n = 12; 32%)c | 359 ± 251 | 400 (10–20,480) |
| EA-R (n = 20; 54%) | 72 ± 23 | 40 (10–2560) |
| EA-DR (n = 5; 14%) | 485 ± 312 | 320 (160–5120) |
| EBNAd | 13 ± 3 | 10 (2.5–160) |
| HIV-1 uninfected | ||
| VCA | ||
| VCA-IgMa | 18 ± 3 | 16 (8–512) |
| VCA-IgGb | 271 ± 32 | 640 (10–10,240) |
| EAs (n = 193) | 112 ± 8e | 160 (10–1280) |
| EA-D (n = 19; 10%)c | 50 ± 10 | 40 (10–320) |
| EA-R (n = 130; 67%) | 92 ± 7 | 80 (10–640) |
| EA-DR (n = 44; 23%) | 281 ± 33 | 320 (40–1280) |
| EBNAd | 14 ± 1 | 10 (2.5–640) |
NOTE. All P values obtained by Wilcoxon rank sum test. EA-D, -R, -DR5EA-diffuse, -restricted, and -diffuse restricted, respectively.
a
P = .53.
b
P = .57.
c
P = .02.
d
P = .59.
e
P = .76.