Table 2.
Type of rt-PA given among all patients and among those with NIHSS recorded
| N (%) or statistics by year | ||||||
|---|---|---|---|---|---|---|
| Variables | Year 2007 | Year 2008 | Year 2009 | Year 2010 | Year 2011 | Year 2012 |
| Total | 13,499 | 22,086 | 27,963 | 35,289 | 40,148 | 43,250 |
| rt-PA group | ||||||
| IV therapy* | 576 (4.3) | 1028 (4.7) | 1482 (5.3) | 2162 (6.1) | 2434 (6.1) | 2923 (6.8)† |
| IA therapy* | 38 (.3) | 178 (.8) | 272 (1.0) | 366 (1.0) | 538 (1.3) | 649 (1.5)† |
| IV + IA therapy* | 10 (.1) | 47 (.2) | 75 (.3) | 124 (.4) | 158 (.4) | 226 (.5)† |
| IV therapy‡ | 130(1.0) | 298 (1.3) | 491 (1.8) | 735 (2.1) | 900 (2.2) | 1109(2.6)† |
| No rt-PA | 12,745 (94.4) | 20,535 (93.0) | 25,643 (91.7) | 31,902 (90.4) | 36,118 (90.0) | 38,343 (88.7) |
| Any rt-PA | 754 (5.6) | 1551 (7.0) | 2320 (8.3) | 3387 (9.6) | 4030 (10.0) | 4907 (11.3)† |
| IV rt-PA only: Symptom onset to treatment time | ||||||
| ≤3 hours | 506 (3.7) | 851 (3.9) | 1163(4.2) | 1657 (4.7) | 1821 (4.5) | 2215 (5.1)† |
| 3-4.5 hours | 33 (.2) | 85 (.4) | 201 (.7) | 373 (1.1) | 463 (1.2) | 547 (1.3)† |
| Beyond 4.5 hours | 3 (.0) | 7 (.0) | 18 (.1) | 38 (.1) | 45 (.1) | 58 (.1) |
| Missing time | 34 (.3) | 85 (.4) | 100 (.4) | 94 (.3) | 105 (.3) | 103 (.2) |
| No IV rt-PA | 12,923 (95.7) | 21,058 (95.3) | 26,481 (94.7) | 33,127 (93.9) | 37,714 (93.9) | 40,327 (93.2) |
| IA rt-PA only: Symptom onset to treatment time | ||||||
| ≤3 hours | 2 (.0) | 15 (.1) | 15 (.1) | 21 (.1) | 31 (.1) | 44 (.1) |
| 3-4.5 hours | 8 (.1) | 28 (.1) | 32 (.1) | 40 (.1) | 53 (.1) | 97 (.2) |
| Beyond 4.5 hours | 10 (.1) | 71 (.3) | 78 (.3) | 81 (.2) | 119 (.3) | 208 (.5)† |
| Missing time | 18 (.1) | 64 (.3) | 147 (.5) | 224 (.6) | 335 (.8) | 300 (.7) |
| No IA rt-PA | 13,461 (99.7) | 21,908 (99.2) | 27,691 (99.0) | 34,923 (99.0) | 39,610 (98.7) | 42,601 (98.5) |
| Among those with NIHSS recorded | ||||||
| Total | 4763 | 8363 | 12,144 | 19,680 | 24,703 | 30,924 |
| IV rt-PA only: Symptom onset to treatment time | ||||||
| ≤3 hours | 384 (8.1) | 666 (8.0) | 857 (7.1) | 1428 (7.3) | 1631 (6.6) | 2109 (6.8)† |
| 3-4.5 hours | 27 (.6) | 58 (.7) | 133 (1.1) | 333 (1.7) | 430 (1.7) | 523 (1.7)† |
| Beyond 4.5 hours | 2 (.0) | 4 (.0) | 12 (.1) | 33 (.2) | 37 (.1) | 55 (.2) |
| Missing time | 21 (.4) | 52 (.6) | 65 (.5) | 82 (.4) | 93 (.4) | 97 (.3) |
| No IV rt-PA | 4329 (90.9) | 7583 (90.7) | 11077 (91.2) | 17804 (90.5) | 22512 (91.1) | 28140 (91.0) |
| IA rt-PA only: Symptom onset to treatment time | ||||||
| ≤3 hours | 1 (.0) | 8 (.1) | 14 (.1) | 20 (.1) | 27 (.1) | 41 (.1) |
| 3-4.5 hours | 6 (.1) | 17 (.2) | 28 (.2) | 37 (.2) | 50 (.2) | 92 (.3) |
| Beyond 4.5 hours | 7 (.1) | 45 (.5) | 60 (.5) | 71 (.4) | 113 (.5) | 190 (.6) |
| Missing time | 11 (.2) | 36 (.4) | 108 (.9) | 181 (.9) | 280 (1.1) | 265 (.9) |
| No IA rt-PA | 4738 (99.5) | 8257 (98.7) | 11,934 (98.3) | 19,371 (98.4) | 24,233 (98.1) | 30,336 (98.1) |
Abbreviations: IA, intra-arterial; IV, intravenous; NIHSS, National Institutes of Health Stroke Scale; rt-PA, recombinant tissue plasminogen activator.
*
Therapy given at participating hospital.
†
F-value for trend was significant at a .05 threshold.
‡
IV rt-PA given at an outside hospital and received in transfer by participating hospital.