56 year old male with T4aN2cM0 OC SCC. Axial (1A), sagittal (1B) and coronal (1C) fused PET/CT images. The figure shows the primary VOI (red) and two outer VOIs (light blue and dark blue). SUV max, SUV mean, MTV, and TLG were calculated from VOIPET (defined by a gradient method using the PET uptake, pink contour). SUV peak was centered on the voxel defined by SUV max. SAM was calculated as the total SUVs from VOISAM less the normal tissue SUVs calculated from the volume between VOISAM (light blue) and VOIBKG (dark blue contour).