Table 2.
Demographic and MRI measures
| 47,XYY | Typically developing controls (TDC) | 48,XXYY | 47,XXY | 48,XXXY | 49,XXXXY | 47,XXX | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N =29 | N =192 | N =20 | N =58 | N =5 | N =6 | N =30 | ||||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | Mean | SD | |
| Demographic measures | ||||||||||||||
| Age | 12.58 | 4.96 | 12.65 | 5.04 | 14.23 | 5.28 | 12.62 | 4.98 | 10.16 | 7.24 | 13.28 | 4.43 | 12.18 | 5.51 |
| Gender (M/F) | 29/0 | 99/93 | 20/0 | 58/0 | 5/0 | 6/0 | 0/30 | |||||||
| Socioeconomic status (SES) | 56.75a | 22.14 | 48.41 | 18.20 | 46.40 | 22.54 | 54.01 | 21.50 | 54.80 | 20.94 | 64.66a | 18.08 | 41.41 | 17.13 |
| Handedness (R/L/M) | 22/4/3 | 164/12/16 | 18/1/1 | 45/6/7 | 4/0/1 | 6/0/0 | 24/2/4 | |||||||
| Full-scale IQ (FSIQ) | 90.58a | 15.41 | 114.50 | 12.56 | 86.52a | 12.71 | 96.78a | 16.65 | 77.33a | 4.72 | 55.50a | 5.91 | 95.30a | 14.42 |
| Verbal IQ (VIQ) | 87.58a | 15.12 | 114.14 | 14.23 | 80.31a | 12.32 | 94.70a | 16.24 | 73.33a | 5.85 | 59.25a | 8.50 | 95.20a | 14.52 |
| Performance-IQ (PIQ) | 95.62a | 17.01 | 111.88 | 11.59 | 95.94a | 12.43 | 98.96a | 16.99 | 86.66a | 7.02 | 57.25a | 3.30 | 96.16a | 15.00 |
| Testosterone replacement therapy (TRT; currently on/ever on/none) | 0/0/0 | 0/0/192 | 7/7/13 | 19/23/35 | 1/2/3 | 3/4/2 | 0/0/0 | |||||||
| MRI measures (cc3) | ||||||||||||||
| Intracranial volume (ICV) | 1.53e +06a | 1.31e +05 | 1.46e +06 | 1.29e +05 | 1.43e +06 | 1.10e +05 | 1.42e +06 | 1.42e +05 | 1.36e +06 | 4.53e +04 | 1.24e +06a | 1.03e +05 | 1.29e +06a | 1.25e +05 |
| Gray matter volume (GM) | 8.81e +05a | 8.69e +04 | 8.43e +05 | 8.67e +04 | 8.17e +05 | 8.24e +04 | 8.14e +05a | 6.74e +04 | 8.08e +05 | 5.83e +04 | 7.21e +05a | 7.98e +04 | 7.55e +05a | 8.77e +04 |
| White matter volume (WM) | 5.18e +05a | 6.27e +04 | 4.89e +05 | 5.91e +04 | 4.91e +05 | 5.82e +04 | 4.75e +05 | 7.52e +04 | 4.46e +05 | 3.51e +04 | 3.99e +05a | 1.23e +04 | 4.20e +05a | 4.20e +05a |
aSignificant group difference between TDC and diagnostic group.