Table 2. Pharmacokinetic Properties of 6 in Rats^a.

	mean i.v.		s.d.
Co (ng/mL)	3021	±	388
t1/2 (h)	0.47	±	0.08
Vdz (L/kg)	1.61	±	0.55
Vdss (L/kg)	1.02	±	0.10
Cl (mL/min/kg)	38.7	±	6.5
AUC0-inf (ng·h/mL)	1042	±	184

	mean p.o.		s.d.
Cmax (ng/mL)	997	±	241
tmax (h)	1.17	±	0.76
t1/2 (h)	2.36	±	0.46
AUC0-inf (ng·h/mL)	4229	±	1892
bioavailability (%)	100

^aMale Sprague–Dawley rat fed (n = 3 per time point); i.v., 2.5 mg/kg; p.o., 10 mg/kg.