Table 4. Total Brain Level Comparison between 6, 9–12, and 18^a,b.

cmpd	6	9	10	11	12	18
fu, brain (rat)c	>0.30	0.026	0.17	0.10	0.10	>0.30
brain 1 h (ng/g)	2730	807	801	895	370	789
B/P 1 h	0.65	0.69	0.44	0.98	1.1	0.61

^aMale Sprague–Dawley rat fed (n = 2 per time point) 10 mg/kg s.c.

^bCompounds were formulated with 20% HPβCD at pH 3.5–4.

^cEstimated unbound drug fraction to rat brain homogenates after 5 h incubation at 37 °C using a Rapid Equilibrium Dialysis device.