Table 2. Summary of the Key in Vitro Properties.
| mouse
microsomal stability |
||||
|---|---|---|---|---|
| cmpd | solubility (μM, pH 6.8) | LogP | ERa (%) | T1/2 (min) |
| 1a | 11 | 4.9 | 66 | 31 |
| 13a | 27 | 4.1 | 49 | 62 |
| 23a | 161 | 4.6 | 91 | 5.8 |
| 14a | 504 | 2.8 | 71 | 24 |
a
Hepatic extraction ratio.
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