Figure 6.

Continuous ELM staining with anti-adherence junction marker in L-ORD mice homozygous for the rd8 mutation. A–F are stained with anti-β-catenin. A, D: Retinal specimen from rd8 free wild-type control mouse (Wt^wt/wt) at 9 months of age. B, E: Retinal specimen from a 5-month-old late-onset retinal degeneration (L-ORD) mouse lacking the rd8 mutation (Ctrp5^+/−;wt/wt). C, F: Retinal specimen from a 12-month-old L-ORD mouse homozygous for the rd8 mutation (Ctrp5^{+/−;rd8/rd8}). Continuous staining is observed across the ELM in all genotypes. The arrows indicate the ELM. Magnification bar=4 μm. ELM, external limiting membrane, ONL, outer nuclear layer, INL, internal nuclear layer.