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. 2015 Jan 29;18(4):pyu055. doi: 10.1093/ijnp/pyu055

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — SH-053-2′F-S-CH₃ selectively reverses the potentiated amphetamine (AMPH) locomotor response in polyriboinosinic-polyribocytidilic acid (POL) offspring. The line plots show the distance moved in the open field as a function of 5min bins during the initial habituation phase and the subsequent AMPH (2.5mg/kg, i.p.) exposure phase separately for control (CON) and (POL) offspring treated with vehicle (0mg/kg SH-053-2′F-S-CH₃) or SH-053-2′F-S-CH₃ (at 15 or 30mg/kg). The bar plot depicts the mean distance moved during the AMPH exposure phase for all groups. *p < 0.05 and **p < 0.01, based on Scheffe’s post hoc analyses. CON, 0mg/kg, n = 11; CON, 15mg/kg, n = 11; CON, 30mg/kg, n = 12; POL, 0mg/kg, n = 11; POL, 15mg/kg, n = 12; and POL, 30mg/kg, n = 11. All values are means ± standard error of the mean.