Figure 2.
Integrated firing rate histograms of dorsal hippocampus CA3 pyramidal neurons showing their responsiveness to the microiontophoretic application of serotonin (5-HT) and intravenous injection of WAY 100635 in vehicle-treated rats (A) and a rat administered with either paroxetine (B; 10mg/kg/d) or bupropion (C; 30mg/kg/d). Note the increase in firing activity of pyramidal neurons after the injection of WAY 100635. (D) Degree (percentage ± SEM) of increase of the firing activity of pyramidal neurons in control rats and those treated with paroxetine and bupropion for 14 days after the administration of WAY 100635. * P<.05, **P<.01.