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. 2015 Jan 24;18(4):pyu052. doi: 10.1093/ijnp/pyu052

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — (S)-3,5-Dihydroxyphenylglycine (DHPG) does not induce long-term depression (LTD) in the dorsolateral striatum (DLS) of adolescent and adult mice. Time course of the effect of DHPG (100 µM for 10 minutes) on the mean (± SEM) amplitude of the field excitatory postsynaptic potentials/population spike (fEPSP/PS) measured in the DLS, expressed as a percentage of baseline, in n=10 slices from adolescent mice (a) and n=9 slices from adult mice (b). Insets show records of fEPSP/PSs measured in 2 slices at the time points indicated on the graphs. Averaged fEPSP/PS amplitude measured 55 to 60 minutes after the start of the perfusion of DHPG in slices from adolescent and adult mice (c). Protein levels of metabotropic glutamate receptor (mGluR)1 (d) and mGluR5 (e) in the DLS of adolescent (n=12) and adult (n=8) mice. #P<.05 (unpaired Student’s t test).