Figure 4.

Influence of DCS administration on MDZ’s and PROP’s effect on memory reconsolidation in animals without memory reactivation.

(A) Timeline for non-reactivated rats from Experiment 2. (B and C) In the absence of a re-exposure session, none of the drug treatments reduced the freezing response on Test 1. (B) CON-SAL/SAL (n = 5), CON-SAL/MDZ (n = 5), CON-DCS/SAL (n = 5), CON-DCS/MDZ (n = 5), ETOH-SAL/SAL (n = 5), ETOH-SAL/MDZ (n = 5), ETOH-DCS/SAL (n = 5) and ETOH-DCS/MDZ (n = 5). (C) CON-SAL/SAL (n = 7), CON-SAL/PROP (n = 7), CON-DCS/SAL (n = 6), CON-DCS/PROP (n = 6), ETOH-SAL/SAL (n = 7), ETOH-SAL/PROP (n = 6), ETOH-DCS/SAL (n = 5), and ETOH-DCS/PROP (n = 5). Data are the mean ± standard error of the mean of time spent freezing during Test 1. CON, control rats; DCS, d-cycloserine; ETOH, ethanol-withdrawn rats; MDZ, midazolam; PROP, propranolol; SAL, sterile saline.