Table 1.

Whole-Brain Results for the Paired-Sample t Tests of gPPI Functional Connectivity for Each Amygdalasubregion

Seed	Direction	Region	MNI Coordinates			Voxels	Z-Score
			X	Y	Z
Left BL	PBO > THC	R cerebelum	38	−42	−32	82	3.02
Left BL	THC > PBO	R Rostral anterior cingulate/mPFC	14	42	12	398	3.65
		L superior frontal gyrus	−18	56	4	104	3.59
Right BL	PBO > THC	R parietal lobe	30	−52	70	111	2.95
Right BL	THC > PBO	Middle cingulate gyrus	−2	26	−10	55	3.31
		L inferior frontal lobe	−46	16	18	84	3.15
Left CM	PBO > THC	R rectus	8	32	−26	114	3.55
Left CM	THC > PBO	L inferior frontal lobe	−42	22	24	180	3.21
Right CM	PBO > THC	L precentral gyrus	−50	−14	58	91	3.63
		R parietal lobe	20	−56	78	66	3.01
Right CM	THC > PBO	None
Left SF	PBO > THC	R precentral gyrus	60	10	46	117	5.19
		L lingual gyrus	−8	−96	−12	131	4.17
		R superior frontal gyrus	30	58	30	57	2.87
Left SF	THC > PBO	R posterior frontal lobe	28	−38	36	456	3.90
		R rostral anterior cingulate/mPFC	14	52	6	760	3.71
		Middle cingulate gyrus	0	−44	42	121	3.23
		L cingulate gyrus	−16	−28	30	67	3.10
		L middle frontal lobe	−20	18	46	212	3.08
Right SF	PBO > THC	R superior frontal gyrus	20	48	22	144	3.60
		R middle temporal gyrus	54	−56	−12	312	3.32
		L cerebelum	−48	−54	−28	63	3.31
		L fusiform gyrus	−26	−94	−24	74	3.28
		R angular gyrus	40	−58	30	164	3.23
		L middle frontal gyrus	−34	58	14	186	3.19
		L inferior parietal lobe	−42	−64	46	74	2.87
Right SF	THC > PBO	None

Reporting of all clusters exhibiting significance threshold at P<.005(uncorrected) with a cluster extent threshold of k (number of contiguous voxels) >50. *Bold italics represent a priori areas of interest for significant, corrected for multiple comparisons. gPPI, generalized form of context-dependent psychophysiological interaction analyses; L, left; MNI,Montreal Neurologic Institute; mPFC, medial prefrontal cortex; PBO, placebo; R,right; SF, superficial; THC, Δ⁹-tetrahydrocannabinol.