Skip to main content
. 2015 Jan 24;18(3):pyu022. doi: 10.1093/ijnp/pyu022

Figure 4.

Figure 4.

Quetiapine inhibits activation of astrocytes in APP/PS1 mice. A, Representatvie immunohistochemical staining using anti-glial fibrillary acidic protein (GFAP) antibody indicated reduced astroglial cell densities in brain sections of treated transgenic mice compared with untreated transgenic mice. Upper panel shows the higher magnification of the field in red frame.The scale bars represent 100 μm (upper) and 500 μm (lower). B, Quantification of cell number in the cerebral cortex showed the GFAP-positive cells were significantly greater in APP/PS1 transgenic mice compared with APP/PS1 transgenic mice treated with quetiapine. C, Immunoblot analysis of GFAP in cerebral cortex. Quantification of GFAP was shown in the graph. Data are expressed as means±SEM, n=4 to 5 mice per group. * P<.05 vs Con; # P<.05 vs transgenic + water.