Figure 5.
Quetiapine reduces proinflammatory cytokines in β-amyloid (Aβ)1-42-treated primary microglia. Primary microglia were pretreated with quetiapine (10 µM) for 1 hour and then with Aβ1–42 (25 µM) for 6 hours. a, Enzyme-linked immunosorbent assay (ELISA) analysis of interleukin 1β (IL-1β). Two-way analysis of variance (ANOVA) showed quetiapine significantly attenuated Aβ-induced IL-1β increase. b, ELISA analysis of tumor necrosis factor α (TNFα). Two-way ANOVA showed exposure of microglia to Aβ increased the secreted TNFα levels. No statistcial significance was detected after quetiapine treatment. Data are expressed as means±SEM, n=4. * P<.05 vs Con; # P<.05 vs Aβ.