Table 1.
The effect of genetic invalidation of 5-HTT on basal 5-HT turnover in various brain areas.
| 5-HTT+/+ | 5-HTT-/- | p-value | |
|---|---|---|---|
| Accumbens | 0.46±0.02 | 0.62±0.01 | p < 0.001 |
| Amygdala | 0.50±0.04 | 0.56±0.02 | n.s. |
| Frontal cortex | 0.52±0.03 | 0.63±0.04 | p = 0.08 |
| Hippocampus | 0.60±0.04 | 1.07±0.04 | p < 0.001 |
| VTA/SN | 0.76±0.04 | 1.61±0.05 | p < 0.001 |
Values are mean 5-HIAA/5-HT ratio ± standard error of the mean (n = 6–8). p-values were determined with the student’s t-test, comparing mice lacking (5-HTT-/-) and posessing (5-HTT+/+) the 5-HT reuptake carrier in each area. VTA/SN: ventral tegmental/substantia nigra.