Table 1.
Effects of 5,7-DHT Infusion in mpFC on 5-HT, NE, and DA Tissue Levels (ng/g Wet Weight) in mpFC Areas (Prelimbic Cortex and Infralimbic Cortex) of the C57 Sham, C57 5-HT–Depleted, DBA Sham, and DBA 5-HT–Depleted Groups
| Sham | 5-HT depleted | |
|---|---|---|
| Prelimbic cortex (C57) | ||
| 5-HT | 815±122 | 147±42** |
| NE | 655±16 | 644± 54 |
| DA | 119±61 | 108±38 |
| Infralimbic cortex (C57) | ||
| 5-HT | 432±90 | 161±37* |
| NE | 398±29 | 405±32 |
| DA | 105±26 | 128±22 |
| Prelimbic cortex (DBA) | ||
| 5-HT | 808±41 | 97±19** |
| NE | 945±48 | 1056±50 |
| DA | 95±3 | 91±4 |
| Infralimbic cortex (DBA) | ||
| 5-HT | 600±39 | 91±13** |
| NE | 875±46 | 1028±70 |
| DA | 156±21 | 177±21 |
Abbreviations: DA, dopamine; DBA, DBA/2J; 5,7-DHT, 5,7-dihydroxytryptamine; 5-HT, serotonin; mpFC, medial prefrontal cortex; NE, noradrenaline.
*P<.01; **P<.001.