Table 2.

Level of Swimming and Struggling Behavior in the FST in C57 Sham, C57 5-HT Depleted in mpFC, DBA Sham, and DBA 5-HT depleted in mpFC Groups

	Swimming	Struggling
C57 sham	139.91±23.34a,b	64.51±10.46
C57 5-HT depleted	221.28±28.96	86.34±15.38
DBA sham	257.91±16.66c	90.69±16.96
DBA 5-HT depleted	345.8±15.89	64.79±6.77

Abbreviations: C57, C57BL/6J; DA, dopamine; DBA, DBA/2J; FST, forced swimming test; 5-HT, serotonin; mpFC, medial prefrontal cortex.

^aC57 sham in comparison with C57 5-HT–depleted group.

^bC57 sham in comparison with DBA sham group.

^cDBA sham in comparison with DBA 5-HT–depleted group.