Figure 40.

A supersandwich strategy for signal amplification in cancer cell analysis. Initially, GCE was modified by oxidized MWCNTs, dopamine, and AuNPs to which Con A was immobilized for detection of a CCRF-CEM cancerous cell line. DNA concatamer was first assembled from a capture DNA-aptamer (CDNA), a CdTe QD-labeled signal DNA (SDNA), and an auxiliary DNA (ADNA). When the cells were attached to the surface, they were probed by a preassembled concatamer, and finally a binding event was detected by an anodic stripping voltammetry of Cd²⁺. Adapted with permission from ref (873). Copyright 2013 American Chemical Society.