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Reagents and conditions: (a) 1. THF, sec-butyllithium, −40 °C to −50 °C; 2. Weinreb amide 19, −50 °C to −10 °C; 3. TFA/DCM; (b) 1. POCl3, DMF; 2. 1 N NaOH; (c) 4-acetylpyridine, piperidine, MeOH.
