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. 2015 Feb 5;58(5):2489–2512. doi: 10.1021/jm501997q

Scheme 6. Synthesis of 2-Hydroxymethyl-5-methoxyindole-pyridinyl-propenone 2p.

Scheme 6

Reagents and conditions: (a) LiAlH4, THF, rt; (b) acetic anhydride, TEA, CH3CN, rt; (c) 1. POCl3, DMF; 2. 1 N NaOH; (d) 4-acetylpyridine, piperidine, MeOH, reflux.