Table 2.
Gene | Gene variant | Risk/non- |
Risk allele frequency (f) |
1P value | OR | 95%CI | |
(SNPs) | risk allele | T2D patients (n = 992) | Controls (n = 294) | for OR | |||
KCNJ11 | rs5219 | T/C | 0.320 | 0.222 | 25.8 × 10-6 | 1.74 | 1.37-2.22 |
TCF7L2 | rs7903146 | T/C | 0.445 | 0.354 | 20.001 | 1.46 | 1.16-1.83 |
CDKAL1 | rs10946398 | C/A | 0.364 | 0.311 | 20.002 | 1.44 | 1.15-1.80 |
CDKN2A/B | rs10811661 | T/C | 0.836 | 0.799 | 0.020 | 1.40 | 1.06-1.84 |
FTO | rs9939609 | A/T | 0.480 | 0.435 | 0.358 | 1.11 | 0.899-1.37 |
FTO | rs8050136 | A/C | 0.458 | 0.425 | 0.770 | 1.03 | 0.829-1.29 |
IGF2BP2 | rs4402960 | T/G | 0.400 | 0.357 | 0.286 | 1.13 | 0.904-1.41 |
SLC30A8 | rs13266634 | C/T | 0.857 | 0.855 | 0.329 | 1.16 | 0.859-1.57 |
CAPN10 | rs3792267 (-43) | G/A | 0.802 | 0.790 | 0.445 | 1.11 | 0.850-1.45 |
HHEX | rs1111875 | T/C | 0.301 | 0.280 | 0.636 | 1.06 | 0.839-1.33 |
1P value: Level of significance;
P value remained significant after correction for multiple testing (< 0.005). The P value, OR and 95%CI were calculated for the association between each gene variant with T2D risk. f: Frequency; T2D: Type 2 diabetes mellitus; SNPs: Single nucleotide polymorphisms.