Table 3.
Gene | Gene variants |
T2D patients |
Controls |
Fst | % variation among T2D and controls | 1P value | ||
F | He | F | He | |||||
KCNJ11 | rs5219 | 0.190 | 0.352 | 0.091 | 0.314 | 0.012 | 2.07 | 0.000 |
TCF7L2 | rs7903146 | 0.017 | 0.486 | 0.000 | 0.476 | 0.009 | 1.62 | 0.000 |
CDKAL1 | rs10946398 | 0.084 | 0.424 | 0.056 | 0.405 | 0.003 | 0.48 | 0.020 |
CDKN2A/B | rs10811661 | 0.000 | 0.275 | 0.003 | 0.320 | 0.002 | 0.37 | 0.042 |
FTO | rs9939609 | 0.000 | 0.502 | 0.000 | 0.497 | 0.002 | 0.31 | 0.050 |
FTO | rs8050136 | 0.006 | 0.493 | 0.000 | 0.503 | 0.001 | 0.12 | 0.147 |
IGF2BP2 | rs4402960 | 0.066 | 0.448 | 0.000 | 0.476 | 0.002 | 0.23 | 0.089 |
SLC30A8 | rs13266634 | 0.061 | 0.230 | 0.188 | 0.201 | 0.000 | 0.00 | 1.000 |
CAPN10 | rs3792267 | 0.057 | 0.300 | 0.000 | 0.335 | 0.000 | 0.00 | 0.517 |
HHEX | rs1111875 | 0.055 | 0.398 | 0.052 | 0.382 | 0.001 | 0.00 | 0.341 |
This provides a measure of genetic differentiation among population; 1P value: Level of significance; F: Fixation index; He: Heterozygosity; Fst: The inbreeding coefficient within subpopulation, relative to total; T2D: Type 2 diabetes mellitus.