Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Clinical cure rates
RCT 6-armed trial	483 women; analysis not by intention to treat; women who did not have positive Candida swabs and did not adhere to protocols were excluded In review	Persistent symptoms 30 days 37/102 (36%) with butoconazole 1% for 3 days 41/95 (43%) with butoconazole 1% for 6 days 31/95 (33%) with butoconazole 2% for 3 days 31/96 (32%) with butoconazole 2% for 6 days 34/95 (36%) with miconazole 2% for 6 days	Reported as not significant P value not reported		Not significant
RCT 3-armed trial	900 women In review	Symptom or mycological failure 7 days 12% with terconazole 0.4% 16% with terconazole 0.8% 19% with miconazole 2% Absolute numbers not reported	Reported as not significant P value not reported		Not significant
RCT 3-armed trial	60 women In review	Persistent symptoms 28 days 7/20 (35%) with high-dose terconazole for 1 day 4/17 (24%) with low-dose terconazole for 3 days 5/23 (22%) with clotrimazole for 3 days	Reported as not significant P value not reported		Not significant
RCT	271 women In review	Persistent symptoms 30 days 22/100 (22%) with butoconazole for 3 days 20/101 (20%) with miconazole for 7 days	P = 0.996		Not significant
RCT	274 women In review	Persistent symptoms 30 days 18% with butoconazole for 3 days 26% with clotrimazole for 3 days Absolute numbers not reported	Reported as not significant P value not reported		Not significant
RCT 3-armed trial	140 women; 130 analysed, not by intention to treat In review	Persistent symptoms 35 days 15/44 (34%) with butoconazole 1% for 6 days 12/45 (27%) with butoconazole 2% for 6 days 14/41 (34%) with miconazole 2% for 6 days	Reported as not significant P value not reported		Not significant
RCT	63 women with mycologically confirmed vulvovaginal candidiasis In review	Less than a 'very good' symptom response 7 days 47% with butoconazole for 3 days 61% with clotrimazole for 6 days Absolute numbers not reported	Reported as not significant P value not reported		Not significant
RCT	217 women; 185 analysed, not by intention to treat In review	Persistent symptoms 30 days 23% with butoconazole for 3 days 31% with clotrimazole for 3 days Absolute numbers not reported	Reported as not significant P value not reported		Not significant
RCT	60 women	Symptoms 4 weeks 1/30 (3%) with clotrimazole for 1 day 2/30 (7%) with econazole for 1 day	Reported as not significant P value not reported		Not significant
RCT	107 women; 101 analysed, not by intention to treat	Mycological failure or persistent symptoms 30 days 2/48 (4%) with flutrimazole for 7 days 7/53 (13%) with clotrimazole for 7 days	Reported as not significant P value not reported		Not significant
RCT	54 women (51 analysed)	Mycological failure or persistent symptoms 7 days 1/26 (4%) with fenticonazole for 7 days 2/30 (7%) with clotrimazole for 7 days	Reported as not significant P value not reported		Not significant
RCT	100 women; 86 analysed, not by intention to treat	Moderate or severe symptoms 7 to 10 days 1/43 (2%) with miconazole for 5 days 2/43 (5%) with clotrimazole for 6 days	Reported as not significant P value not reported		Not significant
RCT	196 women with positive culture for Candida species, about 30% with recurrent candidiasis	Cure rate 28 days 64% with econazole once 65% with isoconazole once Absolute numbers not reported	P = 0.2		Not significant
RCT	223 women	Persistent symptoms 30 days 10/84 (12%) with butoconazole for 1 day 13/93 (14%) with miconazole for 7 days	Reported as not significant P value not reported		Not significant
RCT	369 women (310 analysed; women without positive swab for candidiasis excluded from analysis; not by intention to treat)	Persistent symptoms 1 month 48/139 (35%) with sertaconazole once 52/149 (35%) with econazole once	Reported as not significant P value not reported		Not significant
RCT	80 women	Symptom failure or mycological failure 4 weeks 7/40 (17.5%) with fenticonazole once 8/40 (20.0%) with clotrimazole once	Reported as not significant P value not reported		Not significant
RCT	50 women	Symptoms 21 days 5/17 (29%) with fenticonazole once 4/15 (27%) with clotrimazole once	Reported as not significant P value not reported		Not significant
RCT	60 women	Persistent symptoms 1 month 3/30 (10%) with clotrimazole once 4/30 (13%) with econazole once	Reported as not significant P value not reported		Not significant
RCT	93 women with positive culture for Candida species	Cure rates with clotrimazole for 7 days with miconazole for 7 days Absolute results not reported	Reported as not significant P value not reported		Not significant
RCT	102 married women with positive culture for Candida species	Symptoms 28 days 6/53 (11%) with econazole for 2 days 8/49 (16%) with clotrimazole for 6 days	P >0.05		Not significant
RCT	78 women, 40 non-pregnant	Persistent symptoms 4 weeks 1/20 (5%) with terconazole for 7 days 4/20 (20%) with clotrimazole for 7 days	Reported as not significant P value not reported		Not significant