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. 2015 Mar 16;2015:0815.
Ref (type) Population Outcome, Interventions Results and statistical analysis Effect size Favours
Adverse effects

RCT		 900 women
In review 		Adverse effects
with terconazole 0.4%
with terconazole 0.8%
with miconazole 2%

RCT
3-armed trial 		60 women
In review 		Adverse effects
with terconazole 240 mg for 1 day
with terconazole 80 mg for 3 days
with clotrimazole 200 mg for 3 days

RCT		 271 women
In review 		Adverse effects
with butoconazole for 3 days
with miconazole for 7 days

RCT		 274 women
In review 		Adverse effects
with butoconazole for 3 days
with clotrimazole for 3 days

RCT
3-armed trial 		140 women; 130 analysed, not by intention to treat
In review 		Adverse effects
with butoconazole 1% for 6 days
with butoconazole 2% for 6 days
with miconazole 2% for 6 days

RCT		 63 women with mycologically confirmed vulvovaginal candidiasis
In review 		Adverse effects
with butoconazole for 3 days
with clotrimazole for 6 days

RCT		 217 women; 185 analysed, not by intention to treat
In review 		Adverse effects
with butoconazole for 3 days
with clotrimazole for 3 days

RCT		 60 women Adverse effects
with clotrimazole for 1 day
with econazole for 1 day

RCT		 107 women; 101 analysed, not by intention to treat Adverse effects
with flutrimazole for 7 days
with clotrimazole for 7 days

RCT		 54 women (51 analysed) Adverse effects
with fenticonazole for 7 days
with clotrimazole for 7 days

RCT		 100 women; 86 analysed, not by intention to treat Adverse effects
with miconazole for 5 days
with clotrimazole for 6 days

RCT		 196 women with positive culture for Candida species, about 30% with recurrent candidiasis Adverse effects
with econazole once
with isoconazole once

RCT		 223 women Adverse effects
with butoconazole for 1 day
with miconazole for 7 days

RCT		 369 women (310 analysed; women without positive swab for candidiasis excluded from analysis; not by intention to treat) Itching and burning
9% with sertaconazole
13% with econazole
Absolute numbers not reported
Reported as not significant
P value not reported 		Not significant

RCT		 80 women Adverse effects
with fenticonazole once
with clotrimazole once

RCT		 50 women Adverse effects
with fenticonazole once
with clotrimazole once

RCT		 60 women Adverse effects
with clotrimazole once
with econazole once

RCT		 102 married women with positive culture for Candida species Adverse effects
with econazole for 2 days
with clotrimazole for 6 days		 Not significant

RCT		 78 women, 40 non-pregnant Adverse effects
with terconazole for 7 days
with clotrimazole for 7 days