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. 2015 Feb 4;4(2):e17. doi: 10.1002/psp4.17

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© 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Age-dependent change of allometrically scaled sirolimus clearance from pediatric patients and in vitro intrinsic clearance of sirolimus in individual pediatric liver microsomes. a: The number of patients are 9, 5, 3, and 27 for the age groups: 1–8 months, 1 year (≥1, <2), 2 years (≥2, <3), and 3–18 years, respectively. Statistical P-values are based on nonparametric analysis (Wilcoxon's test). b: Age ranges of donors of liver microsomes were 1-month- to 4-year-old for pediatric (hatched column) and 35- to 48-year-old for adults liver microsomes (open column). N represents the number of individual human liver microsomes in each age group.