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. 2014 Dec 3;5(1):44–48. doi: 10.1159/000369924

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Copyright © 2014 by S. Karger AG, Basel

This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.

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Fig. 1 — a Rarefaction of tubules and glomeruli, severe interstitial inflammatory infiltrates and fibrosis (arrow), PAS ×10. b Interstitial nephritis with dense lymphoplasmacytic infiltrations and eosinophils (arrows), PAS ×400. c The majority of interstitial inflammatory infiltrates were IgG-producing plasma cells (arrows). Immunohistochemistry for IgG, ×400. d The majority (>40%) of IgG+ plasma cells appear positive for IgG4 (arrows). In absolute numbers, >50 IgG4+ plasma cells are seen per hpf. Immunohistochemistry for IgG4, ×400. e Focal thickening of GBMs with C4d positivity indicating MN lesions. Immunohistochemistry for C4d, ×200. f Electron microscopy revealed the presence of subepithelial (arrows) and scarce mesangial deposits compatible with secondary MN, ×15.000.