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. 2015 Mar 16;5:18. doi: 10.3389/fcimb.2015.00018

Figure 1.

Figure 1

Comparisons of the salient pathological findings in the retina and brain of children with CM. (A) Sequestration of late stage malaria parasites in post-capillary venules of the ganglion cell layer and capillaries of the inner nuclear layer and (B) in the cerebral cortex. (C) A thrombus containing vessel in the retina surrounded by hemorrhage is the equivalent of (D) a ring hemorrhage in the cerebral white matter with a central thrombosed microvessel and hemozoin granules. (E) Fibrinogen extravasation in the inner retina and (F) in the brain is associated with prominent iRBC sequestration in the absence of hemorrhage. (G) Axonal damage, indicated by β-APP immunoreactive abnormal axons, in the ganglion cell layer of the retina in the absence of hemorrhage. (H) Diffuse axonal damage in the cerebral white matter in the form of irregular patches of β-APP positive tortuous and swollen axons in areas of heavy iRBC sequestration. A–D: H&E; E, F: fibrinogen; G, H: β-APP. (A–C, E, F, H) x400; (D, H) x200.