Table 2.
Trends in baseline characteristics of patients with ACS according to treatment (N=45 091)
| Palliative (n=1485) |
Conservative (n=11 119) |
Reperfusion (n=32 487) |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1997–2001 | 2002–2005 | 2006–2009 | 2010–2013 | P for trends | P for difference in trends vs reperfusion | 1997–2001 | 2002–2005 | 2006– 2009 | 2010– 2013 | P for trends | P for difference in trends vs reperfusion | 1997–2001 | 2002–2005 | 2006–2009 | 2010– 2013 | P for trends | |
| Number of patients | 414 | 416 | 382 | 273 | 4337 | 2629 | 2277 | 1876 | 4398 | 8411 | 9742 | 9936 | |||||
| Males | 65.5 | 56.3 | 52.6 | 59.0 | 0.018 | 0.003 | 67.6 | 61.4 | 60.3 | 63.8 | <0.001 | <0.001 | 76.6 | 76.9 | 76.6 | 75.6 | 0.19 |
| Age in years, mean (SD) | 78.8 (12) | 77.8 (12) | 80.6 (11) | 75.5 (13) | <0.001 | <0.001 | 68.9 (13) | 74.6 (12) | 75.8 (13) | 73.1 (13) | <0.001 | <0.001 | 62.2 (12) | 62.9 (12) | 63.5 (12) | 64.7 (13) | <0.001 |
| Resuscitation prior to admission | 8.7 | 6.1 | 3.1 | 4.4 | 0.002 | 0.011 | 5.2 | 2.4 | 2.0 | 3.1 | <0.001 | <0.001 | 5.9 | 4.4 | 5.2 | 6.0 | 0.019 |
| Symptoms at admission | |||||||||||||||||
| Pain | 81.6 | 57.8 | 66.3 | 67.3 | <0.001 | <0.001 | 87.4 | 72.5 | 76.4 | 80.5 | <0.001 | <0.001 | 93.2 | 78.3 | 90.3 | 94.4 | <0.001 |
| Dyspnoea | 54.9 | 45.7 | 54.5 | 49.4 | 0.68 | <0.001 | 31.6 | 41.2 | 46.1 | 47.1 | <0.001 | <0.001 | 21.3 | 17.2 | 26.4 | 31.6 | <0.001 |
| Atrial fibrillation | 18.8 | 18.6 | 19.4 | 18.8 | 0.93 | 0.50 | 7.9 | 10.1 | 10.4 | 8.9 | 0.40 | 0.001 | 3.4 | 3.1 | 3.1 | 4.0 | 0.005 |
| STEMI | 51.0 | 41.1 | 32.2 | 29.3 | <0.001 | 0.083 | 48.6 | 39.4 | 35.7 | 33.0 | <0.001 | <0.001 | 78.8 | 63.5 | 59.5 | 58.2 | <0.001 |
| Killip classes 3/4 | 22.3 | 17.8 | 16.4 | 15.6 | 0.019 | 0.002 | 10.0 | 12.0 | 11.1 | 10.3 | 0.53 | <0.001 | 5.3 | 4.1 | 5.7 | 6.8 | <0.001 |
| Hypertension | 62.0 | 71.5 | 81.3 | 79.4 | <0.001 | 0.033 | 55.0 | 70.4 | 76.7 | 75.0 | <0.001 | <0.001 | 47.4 | 54.5 | 59.5 | 60.4 | <0.001 |
| Diabetes | 27.9 | 32.4 | 34.2 | 27.2 | 0.75 | 0.13 | 23.0 | 28.6 | 29.0 | 25.8 | <0.001 | 0.001 | 16.6 | 17.8 | 17.7 | 18.9 | 0.002 |
| Dyslipidaemia | 47.2 | 51.6 | 48.9 | 60.1 | 0.013 | 0.011 | 50.7 | 57.2 | 52.7 | 58.4 | <0.001 | <0.001 | 57.8 | 64.3 | 53.9 | 59.3 | 0.001 |
| Current smoker | 27.6 | 17.2 | 14.7 | 25.1 | 0.088 | 0.001 | 33.0 | 22.9 | 22.7 | 26.1 | <0.001 | <0.001 | 45.6 | 43.7 | 41.8 | 41.6 | <0.001 |
| Obesity (BMI>30) | 15.9 | 18.8 | 18.8 | 21.8 | 0.16 | 0.98 | 19.0 | 16.9 | 18.6 | 19.9 | 0.46 | 0.009 | 17.8 | 19.8 | 21.1 | 22.8 | <0.001 |
| CAD | 56.8 | 52.4 | 50.7 | 40.2 | <0.001 | 0.068 | 46.6 | 51.6 | 51.0 | 40.4 | 0.003 | <0.001 | 34.9 | 32.4 | 34.3 | 29.6 | <0.001 |
| Heart failure | 23.5 | 15.9 | 14.6 | 7.8 | 0.001 | 0.039 | 12.4 | 9.3 | 8.1 | 5.7 | <0.001 | 0.030 | 3.1 | 2.3 | 1.8 | 2.0 | 0.083 |
| Cerebrovascular disease | 17.6 | 13.4 | 14.3 | 14.5 | 0.87 | 0.74 | 8.8 | 11.6 | 10.0 | 9.9 | 0.16 | 0.049 | 5.5 | 4.5 | 4.0 | 5.0 | 0.12 |
| Dementia | 5.9 | 6.6 | 9.4 | 9.3 | 0.14 | 0.47 | 2.1 | 5.1 | 6.2 | 5.9 | 0.050 | 0.008 | 1.2 | 0.5 | 0.6 | 0.7 | 0.004 |
| Lung disease | 14.7 | 14.1 | 8.3 | 11.2 | 0.12 | 0.13 | 16.6 | 10.8 | 10.0 | 9.4 | 0.014 | 0.47 | 9.2 | 4.7 | 4.4 | 4.7 | 0.44 |
| Renal disease | 11.8 | 17.4 | 24.8 | 22.3 | 0.034 | 0.16 | 11.4 | 12.0 | 18.1 | 15.7 | <0.001 | <0.001 | 2.8 | 3.6 | 4.1 | 5.4 | <0.001 |
| Cancer disease | 11.8 | 10.6 | 12.4 | 10.8 | 0.91 | 0.25 | 5.7 | 9.0 | 8.5 | 8.3 | 0.81 | 0.001 | 7.1 | 4.5 | 4.3 | 6.0 | <0.001 |
| CCI>1 | 55.9 | 54.5 | 57.3 | 50.0 | 0.33 | 0.020 | 39.4 | 41.5 | 44.2 | 39.1 | 0.35 | <0.001 | 23.4 | 17.7 | 16.9 | 20.1 | 0.001 |
Age in mean (SD), all other results in percentage.
ACS, acute coronary syndrome; BMI, body mass index; CAD, coronary artery disease; CCI, Charlson comorbidity Index; STEMI, ST-elevation myocardial infarction.