Table III.
Correlation of different factors with smoking by multivariate analys i sa.
| Factors | OR | 95% CI | P-value |
|---|---|---|---|
| In former smokers | |||
| LV density | 1.04 | 1.01-1.1 | 0.024 |
| Presence of iLV | 5.1 | 1.2-21.7 | 0.027 |
| VEGF-D: positive | 3.0 | 1.03-8.4 | 0.043 |
| COX-2: positive | 2.2 | 0.9-5.1 | 0.079 |
| MMP-9: positive | 2.0 | 0.9-4.7 | 0.112 |
| In current smokers | |||
| LV density | 1.1 | 1.01-1.1 | 0.011 |
| Presence of iLV | 9.7 | 2.2-42.3 | 0.003 |
| VEGF-D: positive | 5.3 | 1.8-15.5 | 0.003 |
| COX-2: positive | 3.3 | 1.3-8.7 | 0.014 |
| MMP-9: positive | 3.5 | 1.3-9.0 | 0.011 |
a
Adjusted by pT stage and grade. OR, odds ratio; CI, confidence interval; iLV, intratumoral lymphatic vessel s; COX, cyclooxygenase; MMP, matrix metalloproteinase.