TABLE 1. Patients and disease characteristics.
Characteristics | Number of subjects N=25 |
---|---|
Age median (range) | 55 (34-78) |
Gender (male/female) | 13/12 |
Race | |
Caucasians | 20 |
Hispanic | 3 |
Black | 2 |
Disease | |
Acute lymphoblastic leukemia | 10 |
Chronic lymphocytic leukemia | 5 |
Non-Hodgkin lymphoma | 10 |
Disease status | |
Primary refractory | 11 |
Relapsed refractory | 14 |
Site of disease | |
Marrow | 13 |
Extramedullary ALL | 1 |
Lymph nodes | 15 |
Extra lymphatic sites | 3 |
CD19 and CD22 expression on tumor | |
CD19 only | 11 |
CD22 only | 1 |
CD19 and 22 both | 13 |
Prior therapy | |
Lines median (range) | 5 (1-5) |
Rituximab | 14 |
Ofatumumab | 1 |
Inotuzumab | 1 |
Autologous hematopoietic cell transplantation | 3 |
Allogeneic hematopoietic cell transplantation | 5 |