Table 1b.
Down-regulated proteins identified and quantified by 2D-LC-MALDI-TOF/TOF
| ID | Name | Mice at 6 weeks | Mice at 12 weeks | ||
|---|---|---|---|---|---|
| APOE −/− vs WT | a EF | APOE −/− vs WT | a EF | ||
| Q8VDM4 | 26S proteasome non-ATPase regulatory subunit 2 | e0.53 | 1.9 | ||
| Q00896 | Alpha-1-antitrypsin 1–3 precursor | d0.74 | 1.2 | ||
| O88327 | Alpha-catulin | e0.55 | 1.5 | ||
| Q00623 | b Apolipoprotein A-I precursor | c0.37 | 1.1 | c0.31 | 1.1 |
| P09813 | b Apolipoprotein A-II precursor | c0.20 | 1.5 | c0.17 | 1.3 |
| Q05020 | b Apolipoprotein C-II precursor | e0.36 | 2.0 | e0.31 | EF > 2 |
| P33622 | Apolipoprotein C-III precursor | d0.44 | 1.5 | ||
| P51910 | b Apolipoprotein D precursor | c0.42 | 1.4 | c0.37 | 1.3 |
| P08226 | b Apolipoprotein E precursor | c0.12 | 1.6 | c0.06 | 1.7 |
| P01887 | Beta-2-microglobulin precursor | c0.54 | 1.2 | ||
| P00920 | b Carbonic anhydrase 2 | c0.61 | 1.3 | c0.35 | 1.2 |
| Q06890 | Clusterin precursor | e0.85 | 1.1 | ||
| P01027 | b Complement C3 precursor | c0.69 | 1.1 | c0.68 | 1.1 |
| P01029 | b Complement C4-B precursor | c0.70 | 1.1 | c0.64 | 1.2 |
| P06683 | Complement component C9 precursor | e0.85 | 1.2 | ||
| P04186 | Complement factor B precursor | e0.83 | 1.2 | ||
| Q9JHU4 | b Dynein heavy chain, cytosolic | c0.49 | 1.6 | d0.30 | 1.9 |
| Q8K284 | General transcription factor 3C polypeptide 1 | e0.50 | 1.7 | ||
| Q9JHK4 | b Geranylgeranyl transferase type-2 alpha subunit | e0.19 | EF > 2 | e0.16 | EF > 2 |
| Q91VW5 | Golgin subfamily A member 4 | e0.14 | EF > 2 | ||
| P01898 | b H-2 class I histocompatibility antigen, Q10 alpha chain precursor | c0.38 | 1.2 | c0.33 | 1.2 |
| P63017 | Heat shock cognate 71 kDa protein | d0.71 | 1.1 | ||
| P01942 | b Hemoglobin subunit alpha | c0.55 | 1.1 | c0.32 | 1.1 |
| P02088 | b Hemoglobin subunit beta-1 | c0.46 | 1.3 | c0.26 | 1.3 |
| Q6P2L6 | Histone-lysine N-methyltransferase NSD3 | c0.12 | EF > 2 | ||
| Q61702 | Inter-alpha-trypsin inhibitor heavy chain H1 precursor | e0.79 | 1.3 | ||
| Q61703 | b Inter-alpha-trypsin inhibitor heavy chain H2 precursor | c0.49 | 1.2 | c0.62 | 1.1 |
| Q61730 | Interleukin-1 receptor accessory protein precursor | d0.75 | 1.2 | ||
| P39039 | Mannose-binding protein A precursor | e0.73 | 1.3 | ||
| Q62504 | Msx2-interacting protein | e0.29 | EF > 2 | ||
| Q61171 | b Peroxiredoxin-2 | e0.55 | 1.8 | e0.34 | EF > 2 |
| O70362 | b Phosphatidylinositol-glycan-specific phospholipase D 1 precursor | c0.54 | 1.2 | c0.63 | 1.2 |
| P97290 | Plasma protease C1 inhibitor precursor | d0.70 | 1.2 | ||
| Q8CJ40 | Rootletin | e0.73 | 1.3 | ||
| Q8K1I3 | Secreted phosphoprotein 24 precursor | e0.67 | 1.3 | ||
| P07759 | Serine protease inhibitor A3K precursor | e0.84 | 1.2 | ||
| P05366 | Serum amyloid A-1 protein precursor | c0.27 | 1.5 | ||
| P31532 | b Serum amyloid A-4 protein precursor | c0.46 | 1.5 | c0.49 | 1.3 |
| P52430 | b Serum paraoxonase/arylesterase 1 | e0.57 | 1.7 | d0.51 | 1.5 |
a
The error factor (EF) is an asymmetrical confidence interval, so the true ratio for the protein is expected to be found between the listed ratio multiplied by the EF and the listed ratio divided by the EF at 95% of the time.
b
Proteins are down-regulated at both time points.
c
Probability (p) value is less than 0.001.
d
Probability (p) value is greater than 0.001 but less than 0.01.
e
Probability (p) value is greater than 0.01 but less than 0.05.