Table 2b.
Down-regulated proteins identified and quantified by 2D-LC-ESI-LTQ(PQD)-Orbitrap
| Accession # | Name | Mice at 6 weeks APOE −/− vs WT |
Mice at 12 weeks APOE −/− vs WT |
|---|---|---|---|
| IPI00226680.1 | 10 days neonate cerebellum cDNA | 0.34 | |
| IPI00126208.1 | 11 days embryo whole body cDNA | 0.29 | |
| IPI00468603.4 | 12 days embryo embryonic body between diaphragm region and neck cDNA | 0.28 | |
| IPI00110658.1 | 13 days embryo liver cDNA, RIKEN full-length enriched library, clone:2510040B16 product:hemoglobin, beta adult major chain, full insert sequence | 0.30 | |
| IPI00755200.1 | 221 kDa protein | 0.28 | |
| IPI00649712.1 | *24 kDa protein | 0.38 | 0.32 |
| IPI00349896.3 | *47 kDa protein | 0.50 | 0.21 |
| IPI00350399.6 | *57 kDa protein | 0.49 | 0.29 |
| IPI00380781.2 | Adult male thymus cDNA, RIKEN full-length enriched library, clone:5830476A12 product:complement component 1, r subcomponent-like, full insert sequence | 0.50 | |
| IPI00121209.1 | * Apolipoprotein A-I precursor | 0.39 | 0.32 |
| IPI00136266.1 | * Apolipoprotein C-II precursor | 0.28 | 0.25 |
| IPI00323571.1 | * Apolipoprotein E precursor | 0.09 | 0.07 |
| IPI00130382.3 | * Apolipoprotein M | 0.35 | 0.42 |
| IPI00380509.5 | BC053994 protein | 0.29 | |
| IPI00109966.1 | Beta-2-microglobulin precursor | 0.50 | |
| IPI00121534.8 | Carbonic anhydrase 2 | 0.43 | |
| IPI00121319.1 | Cysteine-rich protein 2 | 0.20 | |
| IPI00128288.2 | * Dimethylaniline monooxygenase [N-oxide-forming] 4 | 0.08 | 0.06 |
| IPI00379245.2 | Glucosamine-6-phosphate isomerase | 0.27 | |
| IPI00319652.1 | Glutathione peroxidase 1 | 0.31 | |
| IPI00109996.1 | * H-2 class I histocompatibility antigen, L-D alpha chain precursor | 0.35 | 0.36 |
| IPI00469114.4 | * Hemoglobin subunit | 0.40 | 0.21 |
| IPI00124725.1 | Inter-alpha-trypsin inhibitor heavy chain H3 precursor | 0.49 | |
| IPI00329872.1 | Isoform 1 of Collagen alpha-1(I) chain precursor | 0.42 | |
| IPI00453688.1 | Isoform 1 of Signal-induced proliferation-associated 1-like protein 1 | 0.20 | |
| IPI00321666.1 | * MHC | 0.40 | 0.41 |
| IPI00117910.2 | Peroxiredoxin-2 | 0.44 | |
| IPI00109437.1 | * Pirin | 0.45 | 0.47 |
| IPI00129965.3 | PREDICTED: alpha-1-B glycoprotein isoform 1 | 0.27 | |
| IPI00355031.5 | PREDICTED: cortactin binding protein 2 isoform 1 | 0.47 | |
| IPI00462565.1 | PREDICTED: similar to 5T4 oncofetal trophoblast glycoprotein | 0.42 | |
| IPI00670418.2 | PREDICTED: similar to jumonji domain containing 1C isoform 3 | 0.21 | |
| IPI00620959.2 | PREDICTED: similar to MAP/microtubule affinity-regulating kinase 3 | 0.15 | |
| IPI00406030.2 | Rho interacting protein 3 | 0.42 | |
| IPI00605003.2 | RING finger protein 17 long transcript | 0.34 | |
| IPI00128040.1 | Serine protease HTRA1 precursor | 0.47 | |
| IPI00135547.1 | Serum amyloid A-4 protein precursor | 0.40 | |
| IPI00317356.9 | * Serum paraoxonase/arylesterase 1 | 0.41 | 0.45 |
| IPI00380247.2 | * SUMO-1-specific protease | 0.45 | 0.39 |
| IPI00116923.1 | Thyroid hormone receptor interactor 10 | 0.25 |
*
Proteins are down-regulated at both time points.