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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Basic Res Cardiol. 2015 Jan 23;110(2):9. doi: 10.1007/s00395-015-0462-0

Fig. 4.

Fig. 4

a Western blot analysis for p-CREB (Ser133) in woodchuck myocardium. Compared to levels in summer without ischemic preconditioning, p-CREB was increased with ischemic preconditioning in summer and more in winter with and without hibernating. GAPDH was used as a loading control. *p <0.05 vs. summer without ischemic preconditioning (IPC). b The infarct size was smaller after CREB virus injection woodchucks in summer, *p <0.05, compared with control LacZ virus. Values are presented as mean ± SEM. These results suggest that the activation of CREB is a novel mechanism involved in the cardioprotection in woodchucks in winter and the cardioprotection induced by IPC in woodchucks in summer