Fig. 5.

Western blot analysis of traditional IPC regulators, PI3K, adenosine A2B receptor and PKCε. a PI3K was significantly upregulated in woodchucks in both winter and summer with IPC, *p <0.05 vs. summer. n = 5 per group. b Adenosine A2B receptor was only increased in woodchucks in summer with IPC, *p <0.05 vs. summer and ^†p <0.05 vs. winter, but did not change in woodchucks in winter or summer without IPC (n = 5 per group). c PKCε phosphorylation was significantly increased in both the summer IPC and winter control animals when compared to the summer control, p <0.05, n = 5 per group. Values are presented as mean ± SEM