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Cholesterol levels in the Dhcr7 siRNA-treated cultures measured by amplex red assay. Compared with the control siRNA (scrambled oligonucleotide), down-regulation of Dhcr7 by siRNAs resulted in a significant reduction of cholesterol production for two of the three specific oligonucleotides (asterisk). The most robust down-regulation was achieved by Dhcr7siRNA No. 3, so this siRNA was used in the subsequent DNA microarray experiments. *P < 0.05.
